Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells | Zendy

Yao Liu | Zendy; Mei Wei | Zendy; Xiang Mao | Zendy; Taisheng Chen | Zendy; Peng Lin | Zendy; Wei Wang | Zendy

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Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells

Author(s) -

Yao Liu,

Mei Wei,

Xiang Mao,

Taisheng Chen,

Peng Lin,

Wei Wang

Publication year - 2021

Publication title -

neural plasticity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.288

H-Index - 68

eISSN - 2090-5904

pISSN - 1687-5443

DOI - 10.1155/2021/5522717

Subject(s) - wnt signaling pathway , protein kinase b , pi3k/akt/mtor pathway , signal transduction , mapk/erk pathway , biology , hearing loss , inner ear , cochlea , sensorineural hearing loss , protein kinase a , neuroscience , microbiology and biotechnology , kinase , medicine , audiology

The loss of auditory sensory hair cells (HCs) is the most common cause of sensorineural hearing loss (SNHL). As the main sound transmission structure in the cochlea, it is necessary to maintain the normal shape and survival of HCs. In this review, we described and summarized the signaling pathways that regulate the development and survival of auditory HCs in SNHL. The role of the mitogen-activated protein kinase (MAPK), phosphoinositide-3 kinase/protein kinase B (PI3K/Akt), Notch/Wnt/Atoh1, calcium channels, and oxidative stress/reactive oxygen species (ROS) signaling pathways are the most relevant. The molecular interactions of these signaling pathways play an important role in the survival of HCs, which may provide a theoretical basis and possible therapeutic interventions for the treatment of hearing loss.

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