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Ginsenoside compound K (G-CK) is a rare ginsenoside originating from the traditional herbal medicine ginseng. Recently, G-CK has been found to cause diarrhea in preclinical researches as a candidate drug. This study is aimed at the potential mechanism of G-CK-induced diarrhea. In this study, we found that the treatment of G-CK significantly increased the peristaltic index (PI) with the intragastric administration of charcoal meal suspension at 90 minutes (not 30 min) after the administration of G-CK and had a clear role in promoting defecation. The Ach and 5-HT levels in colon tissue were not affected by G-CK. Additionally, the clinical trial revealed that subjects with diarrhea had lower exposure and higher  Vz / F of 20(S)-protopanaxadiol (PPD) than nondiarrhea subjects, and there were no statistical differences in the pharmacokinetic parameters of G-CK between diarrhea and nondiarrhea subjects. We therefore concluded that the increased intestinal peristalsis and metabolite 20(S)-PPD were involved in G-CK-induced diarrhea.

Ginsenoside Compound K Promotes Intestinal Peristalsis and the Pharmacokinetic of Metabolite 20(S)-Protopanaxadiol in Relation to Diarrhea