Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions | Zendy

Xin Yi Lim | Zendy; Janice Sue Wen Chan | Zendy; Norfarahana Japri | Zendy; June C. Lee | Zendy; Terence Yew Chin Tan | Zendy

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Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions

Author(s) -

Xin Yi Lim,

Janice Sue Wen Chan,

Norfarahana Japri,

June C. Lee,

Terence Yew Chin Tan

Publication year - 2021

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2021/5511221

Subject(s) - medicine , carica , traditional medicine , adverse effect , drug , clinical trial , cochrane library , pharmacology , toxicology , randomized controlled trial , biology , horticulture

The Carica papaya L. leaf is gaining interest as a potential therapeutic agent for alleviating dengue- and non-dengue-associated thrombocytopaenia. In that regard, safety considerations are as important as efficacy potential. The safety evaluation of botanical products for human use is complicated by variable formulations, complex phytochemical composition, and extrinsic toxicants. This review aimed to systematically collate related safety clinical and preclinical data, as well as reports on herb-drug interactions of C. papaya leaf consumption.Methods A systematic search using predetermined keywords on electronic databases (MEDLINE, Cochrane Library Central, LILACS, and Web of Science) and grey literature was conducted. Relevant clinical and preclinical studies were identified, screened, and analysed to present an overall safety profile of C. papaya leaf consumption.Results A total of 41 articles were included (23 clinical, 5 ongoing trials, and 13 preclinical) for descriptive analysis on study characteristics, adverse reactions, toxicity findings, and herb-drug interactions, from which 13 randomised controlled and quasiexperimental trials were further assessed for risk of bias and reporting quality. Overall, C. papaya leaf consumption (in the form of juice and standardised aqueous extract) was well tolerated by adult humans for short durations (

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