The Regulating Effect of Autophagy-Related MiRNAs in Kidney, Bladder, and Prostate Cancer
Author(s) -
Kai Huang,
Xiaoxin Sun,
Haotian Wu,
Jun Zhao,
Yuli Jian,
Zhongyang Xu,
Shujing Wang,
Deyong Yang
Publication year - 2021
Publication title -
journal of oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.228
H-Index - 54
eISSN - 1687-8469
pISSN - 1687-8450
DOI - 10.1155/2021/5510318
Subject(s) - autophagy , microrna , medicine , prostate cancer , cancer research , cancer , bladder cancer , prostate , kidney cancer , oncology , biology , apoptosis , gene , genetics
Autophagy is a treatment target for many disorders, including cancer, and its specific role is becoming increasingly well known. In tumors, researchers pay attention to microribonucleic acids (miRNAs) with regulatory effects to develop more effective therapeutic drugs for autophagy and find new therapeutic targets. Various studies have shown that autophagy-related miRNAs play an irreplaceable role in different tumors, such as miR-495, miR-30, and miR-101. These miRNAs are associated with autophagy resistance in gastric cancer, non-small cell lung cancer, and cervical cancer. In recent years, autophagy-related miRNAs have also been reported to play a role in autophagy in urinary system tumors. This article reviews the regulatory effects of autophagy-related miRNAs in kidney, bladder, and prostate cancer and provides new ideas for targeted therapy of the three major tumors of the urinary system.
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