High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer | Zendy

Yunqian Cui | Zendy; Fei Meng | Zendy; Wen-Li Zhan | Zendy; ZhouTong Dai | Zendy; Xinghua Liao | Zendy

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High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer

Author(s) -

Yunqian Cui,

Fei Meng,

Wen-Li Zhan,

ZhouTong Dai,

Xinghua Liao

Publication year - 2021

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2021/5282894

Subject(s) - downregulation and upregulation , biology , kidney , cell growth , cancer research , oncology , kidney cancer , renal cell carcinoma , kidney disease , cell , medicine , clear cell renal cell carcinoma , gene , genetics

This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment.

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