Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis | Zendy

Yunfei Wang | Zendy; Long Wang Yue | Zendy; Lechuan Hu | Zendy; Jing Wang | Zendy

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Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis

Author(s) -

Yunfei Wang,

Long Wang Yue,

Lechuan Hu,

Jing Wang

Publication year - 2021

Publication title -

applied bionics and biomechanics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.397

H-Index - 23

eISSN - 1754-2103

pISSN - 1176-2322

DOI - 10.1155/2021/5199278

Subject(s) - nozzle , injector , conical surface , materials science , diffusion , jet (fluid) , subcutaneous tissue , mechanics , penetration (warfare) , process (computing) , biomedical engineering , mechanical engineering , medicine , physics , composite material , engineering , computer science , surgery , thermodynamics , operations research , operating system

In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse.

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