Effect of Gambogic Acid on miR-199a-3p Expression and Cell Biological Behavior in Colorectal Cancer Cells | Zendy

Xiaodong Wang | Zendy; Yingchun Li | Zendy; HaiHua Zhou | Zendy; Ning Han | Zendy; Linlin Pan | Zendy; Yu Chen | Zendy

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Effect of Gambogic Acid on miR-199a-3p Expression and Cell Biological Behavior in Colorectal Cancer Cells

Author(s) -

Xiaodong Wang,

Yingchun Li,

HaiHua Zhou,

Ning Han,

Linlin Pan,

Yu Chen

Publication year - 2021

Publication title -

journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 54

eISSN - 1687-8469

pISSN - 1687-8450

DOI - 10.1155/2021/5140621

Subject(s) - gambogic acid , viability assay , colorectal cancer , medicine , malignancy , microrna , cancer research , cell , cancer , in vitro , oncology , pharmacology , biology , biochemistry , gene

Colorectal cancer (CC), as a malignancy threatening life and health, has a rising incidence in recent years. It has been reported that gambogic acid (GA) has antitumor activity in various tumors, but its effect on CC remains to be elucidated. In this investigation, the influence of GA nanoparticles on microRNA-199a-3p (miR-199a-3p) in CC was analyzed to provide a reliable reference for future clinical practice. Through PCR detection, we first determined that miR-199a-3p presented low expression in CC and had a significant effect in predicting the onset and prognosis of CC. Through in vitro experiments, the enhanced CC cell viability after inhibition was determined; however, decreased cell viability and increased miR-199a-3p level were also observed after GA nanoparticles addition. Hence, GA nanoparticles may influence CC cell biological behaviors by modulating miR-199a-3p, providing a novel treatment scheme for CC in the future.

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