Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds | Zendy

Pavlo Virych | Zendy; О. Nadtoka | Zendy; Volodymyr O. Doroschuk | Zendy; Serhii Lelyushok | Zendy; Vasyl Chumachenko | Zendy; Tetiana Bezugla | Zendy; Nataliya Kutsevol | Zendy

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Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds

Author(s) -

Pavlo Virych,

О. Nadtoka,

Volodymyr O. Doroschuk,

Serhii Lelyushok,

Vasyl Chumachenko,

Tetiana Bezugla,

Nataliya Kutsevol

Publication year - 2021

Publication title -

international journal of polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.399

H-Index - 33

eISSN - 1687-9430

pISSN - 1687-9422

DOI - 10.1155/2021/4935642

Subject(s) - self healing hydrogels , polyacrylamide , cefuroxime , dextran , antimicrobial , antibiotics , in vivo , chemistry , materials science , chromatography , polymer chemistry , biology , biochemistry , organic chemistry , microbiology and biotechnology

Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV method. It is shown that cefuroxime-loaded Dextran/Sulfodextran-graft-polyacrylamide hydrogels release the antibiotic more slowly compared to polyacrylamide hydrogel with the same density of cross-links. Antibacterial activity of the synthesized materials was tested in vitro against wild strains of S. aureus, E. coli, and Klebsiella spp. The possibility of using the obtained antimicrobial hydrogels for the treatment of infected wounds was confirmed in vivo in a rat model.

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