Hair Cell Protection from Ototoxic Drugs | Zendy

Peng Wu | Zendy; Xianmin Wu | Zendy; Chunhong Zhang | Zendy; Xiaoyun Chen | Zendy; Yideng Huang | Zendy; He Li | Zendy

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Hair Cell Protection from Ototoxic Drugs

Author(s) -

Peng Wu,

Xianmin Wu,

Chunhong Zhang,

Xiaoyun Chen,

Yideng Huang,

He Li

Publication year - 2021

Publication title -

neural plasticity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.288

H-Index - 68

eISSN - 2090-5904

pISSN - 1687-5443

DOI - 10.1155/2021/4909237

Subject(s) - ototoxicity , hair cell , programmed cell death , hearing loss , apoptosis , medicine , cisplatin , inner ear , pharmacology , drug , necrosis , apoptotic cell death , regeneration (biology) , neuroscience , audiology , chemistry , biology , pathology , microbiology and biotechnology , chemotherapy , biochemistry , anatomy

Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization.

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