miR-381-3p Involves in Glioma Progression by Suppressing Tumor-Promoter Factor ANTXR1 | Zendy

Zhiqiang Dong | Zendy; Jinglong Zhang | Zendy; Liang Niu | Zendy; Guo-Kuo Hou | Zendy; Zhenshan Gao | Zendy; Qiang Yang | Zendy

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miR-381-3p Involves in Glioma Progression by Suppressing Tumor-Promoter Factor ANTXR1

Author(s) -

Zhiqiang Dong,

Jinglong Zhang,

Liang Niu,

Guo-Kuo Hou,

Zhenshan Gao,

Qiang Yang

Publication year - 2021

Publication title -

computational and mathematical methods in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.462

H-Index - 48

eISSN - 1748-6718

pISSN - 1748-670X

DOI - 10.1155/2021/4883509

Subject(s) - glioma , microrna , downregulation and upregulation , cancer research , tumor progression , biology , microbiology and biotechnology , chemistry , gene , genetics

Accumulating studies revealed association between development of glioma and miRNA dysregulation. A case in point is miR-381-3p, but its mechanism in glioma is unclear yet. In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. Additionally, we also discovered that upregulated anthrax toxin receptor 1 (ANTXR1) was negatively mediated by miR-381-3p. We further proved that miR-381-3p-targeted ANTXR1 was able to counteract the suppression of miR-381-3p on biological functions of glioma. We concluded that miR-381-3p and ANTXR1 were both important factors in modulating glioma progression. miR-381-3p/ANTXR1 axis is expected to be a molecular target for glioma.

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