Plant‐Based Synthesis of Zinc Oxide Nanoparticles (ZnO‐NPs) Using Aqueous Leaf Extract of Aquilegia pubiflora: Their Antiproliferative Activity against HepG2 Cells Inducing Reactive Oxygen Species and Other In Vitro Properties | Zendy

Hasnain Jan | Zendy; Muzamil Shah | Zendy; Anisa Andleeb | Zendy; Shah Faisal | Zendy; Aishma Khattak | Zendy; Muhammad Rizwan | Zendy; Samantha Drouet | Zendy; Christophe Hano | Zendy; Bilal Haider Abbasi | Zendy

Open Access

Plant‐Based Synthesis of Zinc Oxide Nanoparticles (ZnO‐NPs) Using Aqueous Leaf Extract of Aquilegia pubiflora: Their Antiproliferative Activity against HepG2 Cells Inducing Reactive Oxygen Species and Other In Vitro Properties

Author(s) -

Hasnain Jan,

Muzamil Shah,

Anisa Andleeb,

Shah Faisal,

Aishma Khattak,

Muhammad Rizwan,

Samantha Drouet,

Christophe Hano,

Bilal Haider Abbasi

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/4786227

Subject(s) - zeta potential , antioxidant , nuclear chemistry , chemistry , zinc , nanoparticle , aqueous solution , reactive oxygen species , ic50 , viability assay , phytochemical , in vitro , materials science , biochemistry , organic chemistry , nanotechnology

The anti-cancer, anti-aging, anti-inflammatory, antioxidant, and anti-diabetic effects of zinc oxide nanoparticles (ZnO-NPs) produced from aqueous leaf extract of Aquilegia pubiflora were evaluated in this study. Several methods were used to characterize ZnO-NPs, including SEM, FTIR, XRD, DLS, PL, Raman, and HPLC. The nanoparticles that had a size of 34.23 nm as well as a strong aqueous dispersion potential were highly pure, spherical or elliptical in form, and had a mean size of 34.23 nm. According to FTIR and HPLC studies, the flavonoids and hydroxycinnamic acid derivatives were successfully capped. Synthesized ZnO-NPs in water have a zeta potential of -18.4 mV, showing that they are stable solutions. The ZnO-NPs proved to be highly toxic for the HepG2 cell line and showed a reduced cell viability of 23.68 ± 2.1% after 24 hours of ZnO-NP treatment. ZnO-NPs also showed excellent inhibitory potential against the enzymes acetylcholinesterase (IC 50 : 102 μ g/mL) and butyrylcholinesterase (IC 50 : 125 μ g/mL) which are involved in Alzheimer's disease. Overall, the enzymes involved in aging, diabetes, and inflammation showed a moderate inhibitory response to ZnO-NPs. Given these findings, these biosynthesized ZnO-NPs could be a good option for the cure of deadly diseases such as cancer, diabetes, Alzheimer's, and other inflammatory diseases due to their strong anticancer potential and efficient antioxidant properties.

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