Dissecting Sex‐Related Cognition between Alzheimer’s Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies | Zendy

Ghulam Md Ashraf | Zendy; Mahmoud Ahmed Ebada | Zendy; Mohd Suhail | Zendy; Ashraf Ali | Zendy; Md. Sahab Uddin | Zendy; Anwar L. Bilgrami | Zendy; Asma Perveen | Zendy; Amjad Husain | Zendy; Mohammad Tarique | Zendy; Abdul Hafeez | Zendy; Αθανάσιος Αλεξίου | Zendy; Ausaf Ahmad | Zendy; Rajnish Kumar | Zendy; Naheed Banu | Zendy; Agnieszka Najda | Zendy; Amany A. Sayed | Zendy; Ghadeer M. Albadrani | Zendy; Mohamed M. AbdelDaim | Zendy; Ilaria Peluso | Zendy; George E. Barreto | Zendy

Open Access

Dissecting Sex‐Related Cognition between Alzheimer’s Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies

Author(s) -

Ghulam Md Ashraf,

Mahmoud Ahmed Ebada,

Mohd Suhail,

Ashraf Ali,

Md. Sahab Uddin,

Anwar L. Bilgrami,

Asma Perveen,

Amjad Husain,

Mohammad Tarique,

Abdul Hafeez,

Αθανάσιος Αλεξίου,

Ausaf Ahmad,

Rajnish Kumar,

Naheed Banu,

Agnieszka Najda,

Amany A. Sayed,

Ghadeer M. Albadrani,

Mohamed M. AbdelDaim,

Ilaria Peluso,

George E. Barreto

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/4572471

Subject(s) - disease , cognition , diabetes mellitus , alzheimer's disease , medicine , neuroscience , bioinformatics , psychology , biology , endocrinology

The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (A β ) pathogenesis, emphasizing how these drugs act in the male and female brains.

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