Open AccessMeasuring Activated Clotting Time during Cardiac Catheterization and PCI: The Effect of the Sampling Site
Author(s) -
Julius C. Heemelaar,
T. Berkhout,
Antonius A.C.M. Heestermans,
J. C. Zant,
Annemiek M.J. de Vos,
Niels Verouden,
Maurits T. Dirksen,
Jan van Ramshorst
Publication year - 2021
Publication title -
journal of interventional cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.764
H-Index - 51
eISSN - 1540-8183
pISSN - 0896-4327
DOI - 10.1155/2021/4091289
Subject(s) - medicine , cardiac catheterization , activated clotting time , cardiology , catheter , conventional pci , arterial catheter , sampling (signal processing) , nuclear medicine , anesthesia , surgery , cardiopulmonary bypass , filter (signal processing) , myocardial infarction , computer science , computer vision
Results In 100 patients (mean age 67.1, 65% male), no significant differences were observed in ACT values obtained from the guiding catheter and arterial sheath (mean difference (MD) −18.3 s; standard deviation (SD) 96 s; P =0.067). Contrarily, ACT values obtained from the intravenous line were significantly lower as compared to values obtained from the guiding catheter (MD 25.7 s; SD 75.5; P =0.003) and arterial sheath (MD 39 s; SD 102.8; P < 0.001). Furthermore, ACT measurements from the arterial sheath showed a statistically significant proportional bias when compared to the other sampling sites (sheath vs. catheter, r = 0.761, P =0.001; sheath vs. IVL, r = 1.013, P < 0.001).Conclusions The present study shows statistical significance and possibly clinically relevant variations between ACT measurements from different sample sites. Bias in ACT measurements may be minimized by using uniform protocols for ACT measurement during cardiac catheterization.
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