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Background. The use of easily accessible biomarkers for assessing young patients’ health is weighty. This cohort study is aimed at measuring stress/immune biomarkers in the saliva of healthy school-age children and comparing subgroups according to age, sex, and stress perception. Material and Methods. 503 children under 12 years old ( 8.7 ± 1.3 ) were included with anthropometric evaluation (height, waist, hip circumference, body weight, and body mass index (BMI)). Levels of opiorphin (OPI), free cortisol, alpha-amylase (sAA), and secreted immunoglobulin (sIgA) were determined by quantitative assays (ELISA) in unstimulated saliva. Unpaired  t -test, Welch test, and Mann–Whitney  U test were applied for appropriate group comparisons, and the correlation between variables was analyzed with Spearman’s rank coefficient. Results were considered significant at  p &lt; 0.05 . Results. sIgA and sAA exhibited significant differences depending on age and sex: IgA (ng/mL):  86 ± 68.6 vs.  104.9 ± 72.1 for (6-7 y.o.) and (8-11 y.o.), respectively, and  108.1 ± 80.1 vs.  94.6 ± 62.2 for male and females, respectively; sAA (U/mL):  78.9 ± 54.4 vs.  100.5 ± 81.2 for (6-7 y.o.) and (8-11 y.o.). No difference related to age or sex between groups was observed for cortisol and OPI. However, OPI levels were higher and correlated to prior stress exposure in children ( 0.31 ± 0.4 vs.  0.26 ± 0.5   ng / mL ,  p = 0.031 ). sAA was negatively correlated to low mood self-declaration in children in the last two weeks ( r = − 0.10 ,  p = 0.045 ). Conclusions. sIgA and sAA can be used as sex- and age-related biomarkers in children 6-12 y.o., which is not the case for free cortisol and opiorphin. However, OPI reflected previous exposure to stress, suggesting its use for evaluating stress-related changes in children

mediators of inflammation

Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) Related to Age, Sex, and Stress Perception in a Prospective Cohort of Healthy Schoolchildren