Differences of Key Proteins between Apoptosis and Necroptosis | Zendy

Min Yeong Park | Zendy; Sang Eun Ha | Zendy; Preethi Vetrivel | Zendy; Hun Hwan Kim | Zendy; Pritam Bhangwan Bhosale | Zendy; Abuyaseer Abusaliya | Zendy; Gon Sup Kim | Zendy

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Differences of Key Proteins between Apoptosis and Necroptosis

Author(s) -

Min Yeong Park,

Sang Eun Ha,

Preethi Vetrivel,

Hun Hwan Kim,

Pritam Bhangwan Bhosale,

Abuyaseer Abusaliya,

Gon Sup Kim

Publication year - 2021

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2021/3420168

Subject(s) - necroptosis , ripk1 , programmed cell death , microbiology and biotechnology , apoptosis , necrosis , kinase , biology , protein kinase a , cancer cell , caspase , cell type , cell , chemistry , cancer , biochemistry , genetics

Many different types of programmed cell death (PCD) have been identified, including apoptosis and necroptosis. Apoptosis is a type of cell death that is controlled by various genes. It is in charge of eliminating aberrant cells such as cancer cells, replenishing normal cells, and molding the body as it develops. Necroptosis is a type of programmed cell death that combines necrosis and apoptosis. In other words, it takes on a necrotic appearance, although cells die in a controlled manner. Various investigations of these two pathways have revealed that caspase-8, receptor-interacting serine/threonine-protein kinase 1 (RIPK1), and RIPK3 are crucial proteins in charge of the switching between these two pathways, resulting in the activation or inhibition of necroptosis. In this review, we have summarized the key proteins between apoptosis and necroptosis.

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