Clinical Importance of Wnt5a in the Pathogenesis of Colorectal Cancer | Zendy

Mehran Pashirzad | Zendy; Thozhukat Sathyapalan | Zendy; Amirhossein Sahebkar | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Clinical Importance of Wnt5a in the Pathogenesis of Colorectal Cancer

Author(s) -

Mehran Pashirzad,

Thozhukat Sathyapalan,

Amirhossein Sahebkar

Publication year - 2021

Publication title -

journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 54

eISSN - 1687-8469

pISSN - 1687-8450

DOI - 10.1155/2021/3136508

Subject(s) - pathogenesis , colorectal cancer , medicine , cancer , metastasis , cancer research , wnt5a , disease , signal transduction , mouse model of colorectal and intestinal cancer , bioinformatics , wnt signaling pathway , immunology , pathology , biology , genetics

Wnt5a is one of the potent signaling molecules that initiates responses involved in cancer through activation of both canonical and noncanonical signaling cascades. Wnt5a both directly and indirectly triggers cancer-associated signaling pathways based on the cancer type. In colorectal cancer (CRC), altering Wnt5a expression can influence several cellular processes of tumor cells, including proliferation, differentiation, migration, invasion, and metastasis. This review summarizes the molecular mechanisms and clinical importance of Wnt5a in the pathogenesis of CRC for better understanding the pathogenesis and its potential role as a prognostic marker and as an appropriate therapeutic target in the treatment of this disease in the future.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research