Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview | Zendy

Sagar Vyavahare | Zendy; Sandeep Kumar | Zendy; Nicholas Cantu | Zendy; Ravindra Kolhe | Zendy; Wendy B. Bollag | Zendy; Meghan E. McGeeLawrence | Zendy; William Hill | Zendy; Mark W. Hamrick | Zendy; Carlos M. Isales | Zendy; Sadanand Fulzele | Zendy

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Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

Author(s) -

Sagar Vyavahare,

Sandeep Kumar,

Nicholas Cantu,

Ravindra Kolhe,

Wendy B. Bollag,

Meghan E. McGeeLawrence,

William Hill,

Mark W. Hamrick,

Carlos M. Isales,

Sadanand Fulzele

Publication year - 2021

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/2021/2911578

Subject(s) - kynurenine pathway , kynurenine , immune system , covid-19 , tryptophan metabolism , coronavirus , inflammation , biology , tryptophan , immunology , respiratory system , respiratory tract , disease , biological pathway , medicine , bioinformatics , pathology , infectious disease (medical specialty) , biochemistry , amino acid , gene , gene expression

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology.

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