Open AccessCircular RNA mmu_circ_0001598 Contributes to IL-1β-Induced Osteoarthritis Progression by Regulating miR-127-3p
Author(s) -
Xierenguli Apizi,
Dilibaier Talifujiang,
Aziguli Kasimu,
Xue Zhang,
Aibibula Yiming,
Xin Ma,
Qingshan Song,
Dequan Wang
Publication year - 2021
Publication title -
journal of healthcare engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 29
eISSN - 2040-2309
pISSN - 2040-2295
DOI - 10.1155/2021/2793379
Subject(s) - osteoarthritis , gene knockdown , gene silencing , downregulation and upregulation , chondrocyte , cartilage , apoptosis , circular rna , rna interference , cancer research , medicine , degeneration (medical) , microbiology and biotechnology , bioinformatics , chemistry , biology , rna , pathology , gene , anatomy , biochemistry , alternative medicine
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. Accumulating evidence indicates that circular RNAs (circRNAs) play a critical role in various diseases, but the function of circRNAs in OA remains largely unknown. In this study, we found that circ_0001598 was significantly upregulated in chondrocytes treated with IL-1β and in cartilage tissue from mice with severed anterior cruciate ligament surgery (ACLT) induced OA models. Interference with circ_0001598 in vitro restored IL-1β-induced chondrocyte proliferation and apoptosis. Silencing circ_0001598 significantly alleviated ACLT-induced OA in mice. Mechanistically, knockdown of circ_0001598 affected chondrocyte proliferation, apoptosis, and matrix degradation by regulating miR-127-3p. Taken together, our results demonstrate the fundamental role of circ_0001598 and provide new ideas for the prevention and treatment of osteoarthritis.
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