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In this paper, a two-delay HIV-1 virus model with delay-dependent parameters is considered. The model includes both virus-to-cell and cell-to-cell transmissions. Firstly, immune-inactivated reproduction rate  R 0 and immune-activated reproduction rate  R 1 are deduced. When  R 1 &gt; 1 , the system has the unique positive equilibrium  E ∗ . The local stability of the positive equilibrium and the existence of Hopf bifurcation are obtained by analyzing the characteristic equation at the positive equilibrium with the time delay as the bifurcation parameter and four different cases. Besides, we obtain the direction and stability of the Hopf bifurcation by using the center manifold theorem and the normal form theory. Finally, the theoretical results are validated by numerical simulation.

Hopf Bifurcation Analysis of a Two-Delay HIV-1 Virus Model with Delay-Dependent Parameters