Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma | Zendy

Feng Gao | Zendy; Guozhong Liu | Zendy; Jingwen Wang | Zendy; Shirong Huang | Zendy; Fadian Ding | Zendy; Wei Lian | Zendy; Xiaoting Lv | Zendy; Yujia Guo | Zendy; Xiangqun Fan | Zendy; Sheng Zhang | Zendy; Qicai Liu | Zendy

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Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma

Author(s) -

Feng Gao,

Guozhong Liu,

Jingwen Wang,

Shirong Huang,

Fadian Ding,

Wei Lian,

Xiaoting Lv,

Yujia Guo,

Xiangqun Fan,

Sheng Zhang,

Qicai Liu

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/2088345

Subject(s) - pancreatic ductal adenocarcinoma , methylation , adenocarcinoma , pancreatic carcinoma , biology , medicine , cancer research , pancreatic cancer , genetics , cancer , gene

Calcitonin gene-related peptide (CGRP) plays a diverse and intricate role in chronic low-grade inflammation and is closely related to specific cancers. It includes two subtypes, CALCA ( α CGRP) and CALCB ( β CGRP), of which α CGRP expression accounts for more than 90%. Here, we show that methylation of CALCA and CALCB in pancreatic ductal adenocarcinoma was significantly higher than that in paracancer. Western blot and immunohistochemistry showed that CGRP, p-AKT, and p-CREB in the tumor tissues were lower than those in the paracarcinoma tissues. In vivo , the expressions of p-AKT and p-CREB in the pancreatic tissues of CALCA-KO rats were also lower than those of wild type. Methylation of CALCA and CALCB is increased in pancreatic adenocarcinoma, and under that condition, p-AKT and p-CREB levels were decreased.

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