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Methods   In this study, qRT-PCR was used to investigate the expression levels of the  SOX15  gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues. We also investigated the methylation status of the  SOX15  promoter by methylation-specific PCR in tumors and adjacent noncancerous tissues.Results   We observed a statistically significant downregulation of  SOX15  expression in tumors compared to noncancerous tissue samples. The methylation levels of tumors and matched noncancerous tissues were similar, but miR-182, miR-183, and miR-375 expression levels were elevated in tumor tissues compared to noncancerous tissue samples.Conclusions   Our results indicate that  SOX15  gene expression is associated with the pathogenesis of papillary thyroid carcinoma (PTC), and the epigenetic control of the  SOX15  gene is regulated by miRNAs rather than by promoter methylation.

Epigenetic Silencing of SOX15 Is Controlled by miRNAs rather than Methylation in Papillary Thyroid Cancer