Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds | Zendy

Khadijeh Khezri | Zendy; Solmaz Maleki Dizaj | Zendy; Yalda Rahbar Saadat | Zendy; Simin Sharifi | Zendy; Shahriar Shahi | Zendy; Elham Ahmadian | Zendy; Aziz Eftekhari | Zendy; Elaheh Dalir Abdolahinia | Zendy; Farzaneh Lotfipour | Zendy

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Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds

Author(s) -

Khadijeh Khezri,

Solmaz Maleki Dizaj,

Yalda Rahbar Saadat,

Simin Sharifi,

Shahriar Shahi,

Elham Ahmadian,

Aziz Eftekhari,

Elaheh Dalir Abdolahinia,

Farzaneh Lotfipour

Publication year - 2021

Publication title -

stem cells international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.205

H-Index - 64

eISSN - 1687-9678

pISSN - 1687-966X

DOI - 10.1155/2021/1520052

Subject(s) - curcumin , mesenchymal stem cell , microbiology and biotechnology , stem cell , chemistry , signal transduction , biology , biochemistry

The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed.

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