The Role of Inflammasome Activation in Early HIV Infection | Zendy

Cyril Jabea Ekabe | Zendy; Njinju Asaba Clinton | Zendy; Jules Kehbila | Zendy; Ngangom Chouamo Franck | Zendy

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The Role of Inflammasome Activation in Early HIV Infection

Author(s) -

Cyril Jabea Ekabe,

Njinju Asaba Clinton,

Jules Kehbila,

Ngangom Chouamo Franck

Publication year - 2021

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.315

H-Index - 83

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/2021/1487287

Subject(s) - inflammasome , pyroptosis , aim2 , innate immune system , human immunodeficiency virus (hiv) , biology , immunity , immune system , inflammation , caspase 1 , immunology , interferon

The inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated. In this review, we showed that NLRP3 inflammasome activation plays a vital role in inhibiting HIV entry into target cells via the purinergic pathway; IFI16 detects intracellular HIV ssDNA, triggers interferon I and III production, and inhibits HIV transcription; and AIM2 binds to HIV dsDNA and triggers acute inflammation and pyroptosis. Remarkably, by understanding these mechanisms, new therapeutic strategies can be developed against the disease.

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