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Objective   To investigate the antimalarial effects and toxicity of the extracts of the flowers of  Tagetes erecta  L. and the leaves of  Synedrella nodiflora  (L.) Gaertn. in a mouse model.Methods   To determine the  in vivo  antimalarial activity of the extracts, mice were intraperitoneally injected with the  Plasmodium berghei  ANKA strain and then administered  T. erecta  or  S. nodiflora  extract daily for 4 days. Parasitemia was observed by light microscopy. For the detection of acute toxicity, the mice received a single dose of  T. erecta  or  S. nodiflora  extract and were observed for 14 days. Biochemical parameters of liver and kidney function and the histopathology of liver and kidney tissues of the acute toxicity group were then examined.Results    T. erecta  and  S. nodiflora  crude extracts at a dose of 600 mg/kg body weight significantly suppressed parasitemia in malaria-infected mice by 65.65% and 62.65%, respectively. Mice treated with 400 mg/kg  T. erecta  and  S. nodiflora  crude extracts showed 50.82% and 57.67% suppression, and mice treated with 200 mg/kg displayed 26.33% and 38.57% suppression, respectively. Additionally, no symptoms of acute toxicity were observed in the  T. erecta-  and  S. nodiflora -treated groups. Moreover, no significant alterations in the biochemical parameters of liver and kidney function and no histological changes in the liver or kidney tissues were observed.Conclusions   This study revealed that both  T. erecta  and  S. nodiflora  extracts have antimalarial properties  in vivo  with less toxic effects. Further studies are needed to elucidate the mechanisms of the active compounds from both plants.

In Vivo Antimalarial Activity and Toxicity Study of Extracts of Tagetes erecta L. and Synedrella nodiflora (L.) Gaertn. from the Asteraceae Family