Implication of Microsatellite Instability Pathway in Outcome of Colon Cancer in Moroccan Population | Zendy

Fatima El Agy | Zendy; Ihsane El Otmani | Zendy; Asmae Mazti | Zendy; Nada Lahmidani | Zendy; Abdelmalek Oussaden | Zendy; M. El Abkari | Zendy; El Bachir Benjelloun | Zendy; Wadih Moukit | Zendy; Hicham El Bouhaddouti | Zendy; Imane Toughraı | Zendy; Karim Ibn Majdoub Hassani | Zendy; Khalid Maazaz | Zendy; Zineb Benbrahim | Zendy; N. Mellas | Zendy; Karima El Rhazi | Zendy; Karim Ouldim | Zendy; Sanae El Bardai | Zendy; Sidhi Adil Ibrahimi | Zendy; Khalid Ait Taleb | Zendy; S. Bennis | Zendy; Laïla Chbani | Zendy

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Implication of Microsatellite Instability Pathway in Outcome of Colon Cancer in Moroccan Population

Author(s) -

Fatima El Agy,

Ihsane El Otmani,

Asmae Mazti,

Nada Lahmidani,

Abdelmalek Oussaden,

M. El Abkari,

El Bachir Benjelloun,

Wadih Moukit,

Hicham El Bouhaddouti,

Imane Toughraı,

Karim Ibn Majdoub Hassani,

Khalid Maazaz,

Zineb Benbrahim,

N. Mellas,

Karima El Rhazi,

Karim Ouldim,

Sanae El Bardai,

Sidhi Adil Ibrahimi,

Khalid Ait Taleb,

S. Bennis,

Laïla Chbani

Publication year - 2019

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2019/3210710

Subject(s) - microsatellite instability , colorectal cancer , microsatellite , population , outcome (game theory) , cancer , medicine , genetics , oncology , biology , demography , environmental health , gene , sociology , mathematics , allele , mathematical economics

Background Tumors with microsatellite instability (MSI tumors) have distinct clinicopathological features. However, the relation between these tumor subtypes and survival in colon cancer remains controversial. The aim of this study was to evaluate the overall survival (OS) in patients with MSI phenotype, in FES population.Methods The expression of MMR proteins was evaluated by immunohistochemistry for 330 patients. BRAF , KRAS , and NRAS mutations were examined by Sanger sequencing and pyrosequencing methods. The association of MSI status with a patient's survival was assessed by the Kaplan–Meier method and log-rank test.Results The mean age was 54.6 years (range of 19-90 years). The MSI status was found in 11.2% of our population. MSI tumors were significantly associated with male gender, younger patients, stage I-II, right localization, and a lower rate of lymph node and distant metastasis. The OS tends to be longer in MSI tumors than MSS tumors (109.71 versus 74.08), with a difference close to significance ( P = 0.05).Conclusion Our study demonstrates that MSI tumors have a particular clinicopathological features. The results of survival analysis indicate that the MSI status was not predictive of improved overall survival in our context with a lower statistical significance ( P = 0.05) after multivariate analysis.

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