Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders | Zendy

Soichiro Nakahara | Zendy; Megumi Adachi | Zendy; Hiroyuki Ito | Zendy; Mitsuyuki Matsumoto | Zendy; Katsunori Tajinda | Zendy; Theo G.M. van Erp | Zendy

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Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders

Author(s) -

Soichiro Nakahara,

Megumi Adachi,

Hiroyuki Ito,

Mitsuyuki Matsumoto,

Katsunori Tajinda,

Theo G.M. van Erp

Publication year - 2018

Publication title -

neuroscience journal

Language(s) - English

Resource type - Journals

eISSN - 2314-4270

pISSN - 2314-4262

DOI - 10.1155/2018/4852359

Subject(s) - neuroscience , temporal lobe , epilepsy , schizophrenia (object oriented programming) , hippocampus , hippocampal formation , psychosis , dentate gyrus , psychology , psychiatry

Accumulating evidence points to the association of epilepsy, particularly, temporal lobe epilepsy (TLE), with psychiatric disorders, such as schizophrenia. Among these illnesses, the hippocampus is considered the regional focal point of the brain, playing an important role in cognition, psychosis, and seizure activity and potentially suggesting common etiologies and pathophysiology of TLE and schizophrenia. In the present review, we overview abnormal network connectivity between the dentate gyrus (DG) and the Cornus Ammonis area 3 (CA3) subregions of the hippocampus relative to the induction of epilepsy and schizophrenia. In light of our recent finding on the misguidance of hippocampal mossy fiber projection in the rodent model of schizophrenia, we discuss whether ectopic mossy fiber projection is a commonality in order to evoke TLE as well as symptoms related to schizophrenia.

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