Usefulness of Urea as a Means of Improving the Solubility of Poorly Water-Soluble Ascorbyl Palmitate | Zendy

Yutaka Inoue | Zendy; Daichi Niiyama | Zendy; Isamu Murata | Zendy; Ikuo Kanamoto | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Usefulness of Urea as a Means of Improving the Solubility of Poorly Water-Soluble Ascorbyl Palmitate

Author(s) -

Yutaka Inoue,

Daichi Niiyama,

Isamu Murata,

Ikuo Kanamoto

Publication year - 2017

Publication title -

international journal of medicinal chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-2069

pISSN - 2090-2077

DOI - 10.1155/2017/4391078

Subject(s) - chemistry , differential scanning calorimetry , solubility , nuclear chemistry , urea , dpph , scanning electron microscope , organic chemistry , antioxidant , materials science , physics , composite material , thermodynamics

The aim of this study was to evaluate complexes of L-ascorbyl palmitate (ASCP) and urea (UR). This evaluation involved differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), near-infrared spectroscopy (NIR), a solubility test, a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging test, and a mushroom tyrosinase inhibition assay. Physicochemical evaluation revealed that ASCP/UR complexes form at a molar ratio of 1/12. The solubility test revealed that ASCP/UR complexes had increased solubility compared to ASCP. The DPPH radical scavenging test and mushroom tyrosinase inhibition assay revealed that the activity of ASCP/UR complexes was not impaired by complex formation. These results are probably due to the tetragonal crystal system of UR changing to a hexagonal crystal system and interaction with the alkyl group of ASCP.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research