A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites | Zendy

Sira Defaus | Zendy; Maria Gallo | Zendy; María Ángeles Abengózar | Zendy; Luís Rivas | Zendy; David Andreu | Zendy

Open Access

A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites

Author(s) -

Sira Defaus,

Maria Gallo,

María Ángeles Abengózar,

Luís Rivas,

David Andreu

Publication year - 2017

Publication title -

international journal of peptides

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.239

H-Index - 25

eISSN - 1687-9775

pISSN - 1687-9767

DOI - 10.1155/2017/4213037

Subject(s) - paromomycin , aminoglycoside , leishmania , cell penetrating peptide , peptide , cell , antibiotics , microbiology and biotechnology , bioavailability , leishmaniasis , medicine , biology , pharmacology , chemistry , biochemistry , parasite hosting , immunology , world wide web , computer science

A successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetrating peptides as vectors for efficiently transporting low-bioavailability drugs into cells.

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