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High-throughput genomic technology has enabled us to screen the entire genome and generate hypotheses at relatively low costs. One of the driving forces in highthroughput genomic technology is high-throughput sequencing (HTS).With its rapid development and affordability, HTS has quickly become the go-to choice for interrogating the entire genome. The analysis methodology development for HTS has been at the forefront of bioinformatics in recent years. Hundreds of tools and pipelines have been developed to aid researchers in interpreting HTS data. The aim of this special issue is to promote research and reflect the most recent advances in addressing HTS data analysis. We received a total of 14 manuscripts and, through rigorous review, selected six for publication in this special issue. What follows is a brief summary of the six manuscripts:

Recent Advances in High Throughput Sequencing Analysis