Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors | Zendy

Mahadev N. Kumbar | Zendy; Ravindra R. Kamble | Zendy; Atulkumar A. Kamble | Zendy; Sujith Raj Salian | Zendy; Sandhya Kumari | Zendy; Ramya Nair | Zendy; Guruprasad Kalthur | Zendy; Satish Kumar Adiga | Zendy; Jagadeesh Prasad Dasappa | Zendy

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Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors

Author(s) -

Mahadev N. Kumbar,

Ravindra R. Kamble,

Atulkumar A. Kamble,

Sujith Raj Salian,

Sandhya Kumari,

Ramya Nair,

Guruprasad Kalthur,

Satish Kumar Adiga,

Jagadeesh Prasad Dasappa

Publication year - 2016

Publication title -

international journal of medicinal chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-2069

pISSN - 2090-2077

DOI - 10.1155/2016/9890630

Subject(s) - benzimidazole , coumarin , microwave irradiation , chemistry , phosphodiesterase , pyrazole , combinatorial chemistry , microwave , motility , stereochemistry , biochemistry , organic chemistry , enzyme , biology , computer science , catalysis , telecommunications , genetics

Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d , 5e , 5f , 5g , 5h , and 5k, have exhibited potent inhibitory activity on PDE.

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