Identification and Optimisation of Lipase-Catalysed Synthesis of Betulinic Acid Amide in a Solvent System | Zendy

Nurul Atikah Binti Amin Yusof | Zendy; Nursyamsyila Mat Hadzir | Zendy; Siti Efliza Ashari | Zendy

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Identification and Optimisation of Lipase-Catalysed Synthesis of Betulinic Acid Amide in a Solvent System

Author(s) -

Nurul Atikah Binti Amin Yusof,

Nursyamsyila Mat Hadzir,

Siti Efliza Ashari

Publication year - 2016

Publication title -

journal of applied chemistry

Language(s) - English

Resource type - Journals

eISSN - 2314-6923

pISSN - 2356-7171

DOI - 10.1155/2016/5149326

Subject(s) - betulinic acid , chemistry , amide , solvent , chloroform , organic chemistry , substrate (aquarium) , hexane , chromatography , genetics , oceanography , biology , geology

Betulinic acid amide was synthesized from the enzymatic reaction of betulinic acid and butylamine catalysed by Novozym 435. The effects of different reaction parameters, such as effect of reaction time, reaction temperature, amount of enzyme, and substrate molar ratio (betulinic acid : butylamine), were studied and conventionally optimised. Based on this study, the enzymatic synthesis of betulinic acid amide was found to be 64.6% at the optimum conditions of 24 h, 40°C, 100 mg enzyme, and 1 : 1 substrate molar ratio in 9 : 1 mixture of chloroform and hexane as solvent. The identification of final product was carried out using TLC, melting point, and FTIR and NMR showed the presence of betulinic acid amide

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