Targeted Strategies to Modulate Stem-Cell-Relevant Pathways | Zendy

Jonathan W. Lowery | Zendy; James A. Ankrum | Zendy; Shoichiro Kokabu | Zendy; Renjing Liu | Zendy

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Targeted Strategies to Modulate Stem-Cell-Relevant Pathways

Author(s) -

Jonathan W. Lowery,

James A. Ankrum,

Shoichiro Kokabu,

Renjing Liu

Publication year - 2016

Publication title -

stem cells international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.205

H-Index - 64

eISSN - 1687-9678

pISSN - 1687-966X

DOI - 10.1155/2016/1859456

Subject(s) - stem cell , cell type , neuroscience , signal transduction , biology , stem cell biology , bioinformatics , cell , computational biology , medicine , microbiology and biotechnology , genetics , embryo , reproductive technology , embryogenesis

Modulation of stem cell behavior is of significant interest to the biomedical community and could lead to novel therapeutic advances in treating disease. Achieving this goal requires specific strategies that manipulate the pathways regulating stem cell plasticity and behavior. The accumulating evidence indicates that just a few main signaling pathways regulate most types of stem cells, which suggests that strategies that modulate one type of stem cell might hold broad usefulness. However, as stem cell research becomes more and more specialized, investigators studying a particular pathway or behavior in one specialty can miss a breakthrough advancement made in another specialty.

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