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Modulation of stem cell behavior is of significant interest to the biomedical community and could lead to novel therapeutic advances in treating disease. Achieving this goal requires specific strategies that manipulate the pathways regulating stem cell plasticity and behavior. The accumulating evidence indicates that just a few main signaling pathways regulate most types of stem cells, which suggests that strategies that modulate one type of stem cell might hold broad usefulness. However, as stem cell research becomes more and more specialized, investigators studying a particular pathway or behavior in one specialty can miss a breakthrough advancement made in another specialty.

Targeted Strategies to Modulate Stem-Cell-Relevant Pathways