Diclofenac Potassium Transdermal Patches Using Natural Rubber Latex Biomembranes as Carrier | Zendy

Natan Roberto de Barros | Zendy; Paulo Augusto Marques Chagas | Zendy; Felipe Azevedo Borges | Zendy; José Lúcio Pádua Gemeinder | Zendy; Matheus Carlos Romeiro Miranda | Zendy; Bruna Cambraia Garms | Zendy; Rondinelli Donizetti Herculano | Zendy

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Diclofenac Potassium Transdermal Patches Using Natural Rubber Latex Biomembranes as Carrier

Author(s) -

Natan Roberto de Barros,

Paulo Augusto Marques Chagas,

Felipe Azevedo Borges,

José Lúcio Pádua Gemeinder,

Matheus Carlos Romeiro Miranda,

Bruna Cambraia Garms,

Rondinelli Donizetti Herculano

Publication year - 2015

Publication title -

journal of materials

Language(s) - English

Resource type - Journals

eISSN - 2314-4874

pISSN - 2314-4866

DOI - 10.1155/2015/807948

Subject(s) - transdermal , transdermal patch , fourier transform infrared spectroscopy , ketoprofen , natural rubber , chemistry , materials science , potassium , pharmacology , nuclear chemistry , chemical engineering , chromatography , medicine , organic chemistry , engineering

The aim of this study was to design a compound transdermal patch containing diclofenac potassium (Dic-K) using natural rubber latex (NRL) biomembrane. The NRL from Hevea brasiliensis is easily manipulated and low cost and presents high mechanical resistance. It is a biocompatible material which can stimulate natural angiogenesis and is capable of adhering cells on its surface. Recent researches have used the NRL for Transdermal Drug Delivery Systems (TDDSs). Dic-K is used for the treatment of rheumatoid arthritis and osteoarthritis and pain relief for postoperative and posttraumatic cases, as well as inflammation and edema. Results showed that the biomembrane can release Dic-K for up to 216 hours. The kinetics of the Dic-K release could be fitted with double exponential function. X-ray diffraction and Fourier Transform Infrared (FTIR) spectroscopy show some interaction by hydrogen bound. The results indicated the potential of the compound patch

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