Human Urine Proteomics: Analytical Techniques and Clinical Applications in Renal Diseases | Zendy

Shiva Kalantari | Zendy; Ameneh Jafari | Zendy; Raheleh Moradpoor | Zendy; Elmira Ghasemi | Zendy; Ensieh Khalkhal | Zendy

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Human Urine Proteomics: Analytical Techniques and Clinical Applications in Renal Diseases

Author(s) -

Shiva Kalantari,

Ameneh Jafari,

Raheleh Moradpoor,

Elmira Ghasemi,

Ensieh Khalkhal

Publication year - 2015

Publication title -

international journal of proteomics

Language(s) - English

Resource type - Journals

eISSN - 2090-2174

pISSN - 2090-2166

DOI - 10.1155/2015/782798

Subject(s) - proteomics , lupus nephritis , biomarker discovery , medicine , membranous nephropathy , focal segmental glomerulosclerosis , proteome , biomarker , diabetic nephropathy , urinary system , urine , bioinformatics , proteinuria , kidney , pathology , disease , biology , biochemistry , gene

Urine has been in the center of attention among scientists of clinical proteomics in the past decade, because it is valuable source of proteins and peptides with a relative stable composition and easy to collect in large and repeated quantities with a noninvasive procedure. In this review, we discuss technical aspects of urinary proteomics in detail, including sample preparation, proteomic technologies, and their advantage and disadvantages. Several recent experiments are presented which applied urinary proteome for biomarker discovery in renal diseases including diabetic nephropathy, immunoglobulin A (IgA) nephropathy, focal segmental glomerulosclerosis, lupus nephritis, membranous nephropathy, and acute kidney injury. In addition, several available databases in urinary proteomics are also briefly introduced.

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