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Quorum sensing (QS) is a key regulator of virulence factors and biofilm formation in Gram-negative bacteria such as  Pseudomonas aeruginosa . Microorganisms that inhabit soil are of strategic importance in the discovery of compounds with anti-QS properties. The objective of the study was to test the culture extract of a taxonomically novel species of  Paenibacillus  strain 139SI for its inhibitory effects on the QS-controlled virulence factors and biofilm formation of  Pseudomonas aeruginosa  both  in vitro  and  in vivo . The  Paenibacillus  sp. culture extract was used to test its anti-QS effects on the LasA protease, LasB elastase, pyoverdin production, and biofilm formation of  P. aeruginosa  as well as evaluate its therapeutic effects on lung bacteriology, pathology, hematological profile, and serum antibody responses of experimental animals in a rat model of chronic lung infection. Results showed significant decrease in the activities of QS-controlled LasA protease, LasB elastase pyoverdin, and biofilm formation of  P. aeruginosa  caused by the culture extract. Moreover, the extract significantly prolonged the survival times of rats and facilitated the clearance of biofilm infections from infected lungs. In conclusion, the antiquorum sensing effects of culture extract from a novel species of  Paenibacillus  provide new insights to combat biofilm-associated infections.

international journal of bacteriology

Inhibition of Quorum Sensing-Controlled Virulence Factors and Biofilm Formation in <i>Pseudomonas aeruginosa</i> by Culture Extract from Novel Bacterial Species of <i>Paenibacillus</i> Using a Rat Model of Chronic Lung Infection

Inhibition of Quorum Sensing-Controlled Virulence Factors and Biofilm Formation in Pseudomonas aeruginosa by Culture Extract from Novel Bacterial Species of Paenibacillus Using a Rat Model of Chronic Lung Infection