FOXO3a Gene Polymorphism Associated with Asthma in Indian Population | Zendy

Shravani Barkund | Zendy; Tejas Shah | Zendy; Nikhil Ambatkar | Zendy; Maithili S. Gadgil | Zendy; Kalpana Joshi | Zendy

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FOXO3a Gene Polymorphism Associated with Asthma in Indian Population

Author(s) -

Shravani Barkund,

Tejas Shah,

Nikhil Ambatkar,

Maithili S. Gadgil,

Kalpana Joshi

Publication year - 2015

Publication title -

molecular biology international

Language(s) - English

Resource type - Journals

eISSN - 2090-2190

pISSN - 2090-2182

DOI - 10.1155/2015/638515

Subject(s) - asthma , medicine , single nucleotide polymorphism , rheumatoid arthritis , immunology , copd , population , gene , disease , polymorphism (computer science) , genetics , genotype , biology , environmental health

Asthma is a chronic inflammatory disorder delineated by a heightened immunological response due to environmental or genetic factors. Single nucleotide polymorphism studies have shown that FOXO3a plays a pivotal role in maintaining immunoregulation. Polymorphism in FOXO3a has been linked to inflammatory diseases such as chronic obstructive pulmonary disease (COPD), Rheumatoid Arthritis, and Crohn's disease suggesting that FOXO3a may be associated with asthma. Airway inflammation in asthma is characterized by activation of T helper type 2 (Th2) T cells and Foxo family members are reported to play critical roles in the suppression of T cell activation. Thus this study was undertaken to investigate an association between single nucleotide polymorphism of the FOXO3a (rs13217795, C>T transition) gene and asthma in Indian population. To our knowledge we are the first ones reporting an association between FOXO3a and asthma.

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