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A series of new 2,4,6-trisubstituted- s -triazine was synthesized, assessed for antimicrobial activity, and characterized by FTIR,  1 HNMR,  13 CNMR, and elemental analysis. The tested compounds,  4d ,  4g ,  4h ,  4k , and  4n , have shown considerable  in vitro  antibacterial efficacy with reference to the standard drug ciprofloxacin (MIC 3.125  μ gmL −1  against  B. subtilis ,  E. coli , and  K. pneumoniae ). It was observed that compounds  4d  and  4h  displayed equipotent antibacterial efficacy against  B. subtilis  (MIC 3.125  μ gmL −1 ) and  S. aureus  (MIC 6.25  μ gmL −1 ). The studies demonstrated that the  para -fluorophenylpiperazine substituted  s -triazine ( 4n ) was potent and exhibited broad spectrum antibacterial activity against  S. epidermidis ,  K. pneumoniae , and  P. aeruginosa  with MIC of 6.25  μ gmL −1  and for  E. coli , it showed an MIC of 3.125  μ gmL −1  equipotent with reference to the standard drug. Among all the compounds under investigation, compound  4g  also demonstrated significant antifungal activity (3.125  μ gmL −1 ) against  C. albicans .

international journal of medicinal chemistry

Facile Synthesis, Characterization, and <i>In Vitro</i> Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-<i>s</i>-triazine Based Compounds

Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds