Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds

A series of new 2,4,6-trisubstituted- s -triazine was synthesized, assessed for antimicrobial activity, and characterized by FTIR, 1 HNMR, 13 CNMR, and elemental analysis. The tested compounds, 4d , 4g , 4h , 4k , and 4n , have shown considerable in vitro antibacterial efficacy with reference to the standard drug ciprofloxacin (MIC 3.125  μ gmL −1 against B. subtilis , E. coli , and K. pneumoniae ). It was observed that compounds 4d and 4h displayed equipotent antibacterial efficacy against B. subtilis (MIC 3.125  μ gmL −1 ) and S. aureus (MIC 6.25  μ gmL −1 ). The studies demonstrated that the para -fluorophenylpiperazine substituted s -triazine ( 4n ) was potent and exhibited broad spectrum antibacterial activity against S. epidermidis , K. pneumoniae , and P. aeruginosa with MIC of 6.25  μ gmL −1 and for E. coli , it showed an MIC of 3.125  μ gmL −1 equipotent with reference to the standard drug. Among all the compounds under investigation, compound 4g also demonstrated significant antifungal activity (3.125  μ gmL −1 ) against C. albicans .