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Simple, rapid spectrophotometric, and reverse-phase high performance liquid chromatographic methods were developed for the concurrent analysis of 17-beta-estradiol (ESR) and drospirenone (DRS). The spectrophotometric method was based on the determination of first derivative spectra and determined ESR and DRS using the zero-crossing technique at 208 and 282 nm, respectively, in methanol. The linear range was 0.5–32.0  µ g·mL −1  for DRS and 0.5–8.0  µ g·mL −1  for EST. The limit of detection (LOD) values were 0.14  µ g·mL −1  and 0.10  µ g·mL −1  and limit of quantification (LOQ) values were 0.42  µ g·mL −1  and 0.29  µ g·mL −1  for ESR and DRS, respectively. The chromatographic method was based on the separation of both analytes on a C 18  column with a mobile phase containing acetonitrile and water (70 : 30, v/v). Detection was performed with a UV-photodiode array detector at 279 nm. The linear range was 0.08–2.5  µ g·mL −1  for DRS and 0.23–7.5  µ g·mL −1  for EST. LOD values were 0.05  µ g·mL −1  and 0.02  µ g·mL −1  and LOQ values were 0.15  µ g·mL −1  and 0.05  µ g·mL −1  for ESR and DRS, respectively. These recommended methods have been applied for the simultaneous determination of ESR and DRS in their tablets.

international scholarly research notices

Development of Simultaneous Derivative Spectrophotometric and HPLC Methods for Determination of 17-Beta-Estradiol and Drospirenone in Combined Dosage Form