Histological and Biochemical Evaluation of the Kidney following Chronic Consumption of Hibiscus sabdariffa | Zendy

U Ukoha | Zendy; Smart Ikechukwu Mbagwu | Zendy; Godwin U Ndukwe | Zendy; C. Obiagboso | Zendy

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Histological and Biochemical Evaluation of the Kidney following Chronic Consumption of Hibiscus sabdariffa

Author(s) -

U Ukoha,

Smart Ikechukwu Mbagwu,

Godwin U Ndukwe,

C. Obiagboso

Publication year - 2015

Publication title -

advances in biology

Language(s) - English

Resource type - Journals

eISSN - 2356-6582

pISSN - 2314-7563

DOI - 10.1155/2015/486510

Subject(s) - hibiscus sabdariffa , kidney , hibiscus , histology , aqueous extract , medicine , traditional medicine , body weight , renal function , pharmacology , biology , pathology , botany

Hibiscus sabdariffa L. has been used traditionally as herbal medicine and has been documented to have a broad range of therapeutic effects. The present study aimed to investigate the effects of chronic administration of aqueous extract of flowers of Hibiscus sabdariffa on the histology of the kidney and some biochemical indices of renal function in male Wistar rats. Twenty (20) Wistar rats were randomly divided into four (4) groups of five rats each. The extract was administered orally in doses 200, 500, and 800 mg/kg body weight for 21 days. The kidney was harvested and processed histologically and blood samples were taken for biochemical assays. The histological results showed dose dependent pathological states and the biochemical analysis revealed a dose dependant variation in renal indices. These results suggest that chronic administration of aqueous extract of Hibiscus sabdariffa may be toxic to the kidney

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