Investigation of Fatty Acid Ketohydrazone Modified Liposome’s Properties as a Drug Carrier | Zendy

Keita Hayashi | Zendy; Madoka Kiriishi | Zendy; Keishi Suga | Zendy; Yukihiro Okamoto | Zendy; Hiroshi Umakoshi | Zendy

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Investigation of Fatty Acid Ketohydrazone Modified Liposome’s Properties as a Drug Carrier

Author(s) -

Keita Hayashi,

Madoka Kiriishi,

Keishi Suga,

Yukihiro Okamoto,

Hiroshi Umakoshi

Publication year - 2015

Publication title -

journal of drug delivery

Language(s) - English

Resource type - Journals

eISSN - 2090-3014

pISSN - 2090-3022

DOI - 10.1155/2015/481670

Subject(s) - liposome , chemistry , stearic acid , membrane , amphiphile , laurdan , chromatography , drug delivery , palmitic acid , biophysics , membrane fluidity , biochemistry , fatty acid , organic chemistry , copolymer , biology , polymer

pH-responsive liposomes were prepared by modifying the liposome with acid-cleaving amphiphiles. Palmitic ketohydrazone (P-KH) or stearic ketohydrazone (S-KH), composed of hydrophilic sugar headgroup and hydrophobic acyl chain, was used as a modifier of the DMPC liposome. Because the ketohydrazone group of P-KH or S-KH was cleaved at low pH conditions (

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