Identification of Proximal and Distal 22q11.2 Microduplications among Patients with Cleft Lip and/or Palate: A Novel Inherited Atypical 0.6 Mb Duplication | Zendy

Maryam Sedghi | Zendy; Hossein Abdali | Zendy; Mehrdad Memarzadeh | Zendy; Mansoor Salehi | Zendy; Narges Nouri | Zendy; Majid Hosseinzadeh | Zendy; Nayereh Nouri | Zendy

Open Access

Identification of Proximal and Distal 22q11.2 Microduplications among Patients with Cleft Lip and/or Palate: A Novel Inherited Atypical 0.6 Mb Duplication

Author(s) -

Maryam Sedghi,

Hossein Abdali,

Mehrdad Memarzadeh,

Mansoor Salehi,

Narges Nouri,

Majid Hosseinzadeh,

Nayereh Nouri

Publication year - 2015

Publication title -

genetics research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.351

H-Index - 9

eISSN - 2090-3154

pISSN - 2090-3162

DOI - 10.1155/2015/398063

Subject(s) - multiplex ligation dependent probe amplification , gene duplication , medicine , phenotype , genetics , genetic counseling , copy number variation , multiplex , bioinformatics , biology , gene , genome , exon

Misalignments of low-copy repeats (LCRs) located in chromosome 22, particularly band 22q11.2, predispose to rearrangements. A variety of phenotypic features are associated with 22q11.2 microduplication syndrome which makes it challenging for the genetic counselors to recommend appropriate genetic assessment and counseling for the patients. In this study, multiplex ligation probe dependent amplification (MLPA) analysis was performed on 378 patients with cleft lip and/or palate to characterize rearrangements in patients suspected of 22q11.2 microduplication and microdeletion syndromes. Of 378 cases, 15 were diagnosed with a microdeletion with various sizes and 3 with duplications. For the first time in this study an atypical 0.6 Mb duplication is reported. Illustration of the phenotypes associated with the microduplications increases the knowledge of phenotypes reported in the literature.

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