Drug Resistance in Hematologic Malignancies: Induction Mechanisms, Genetics, and Therapeutics

Hematopoietic malignancies are neoplastic tumors affecting the blood and lymphatic circulatory systems and are commonly referred to as liquid tumors. Malignancies of the blood and lymphatic systems are known to affect a whole host of cell types derived from lymphoid and myeloid progenitors including leukocytic and lymphatic cells and cells that make up the bone marrow microenvironment (Table 1). Due to the variety of cells affected, hematological malignancies of one tissue type can often result in complications with the other hematologic systems.