Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study | Zendy

Helen Chattopadhyay | Zendy; A. De | Zendy; Sriparna Datta | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study

Author(s) -

Helen Chattopadhyay,

A. De,

Sriparna Datta

Publication year - 2015

Publication title -

international scholarly research notices

Language(s) - English

Resource type - Journals

ISSN - 2356-7872

DOI - 10.1155/2015/261476

Subject(s) - polyvinyl alcohol , factorial experiment , polymer , materials science , microparticle , starch , chemical engineering , drug delivery , emulsion , fourier transform infrared spectroscopy , nanotechnology , chemistry , composite material , computer science , organic chemistry , engineering , machine learning

The aim of our present work was to optimize the ratio of a very novel polymer, starch-polyvinyl alcohol (PVA), for controlled delivery of Ornidazole. Polymer-coated drug microparticles were prepared by emulsion method. Microscopic study, scanning electron microscopic study, and atomic force microscopic study revealed that the microparticles were within 10 micrometers of size with smooth spherical shape. The Fourier transform infrared spectroscopy showed absence of drug polymer interaction. A statistical 3 2 full factorial design was used to study the effect of different concentration of starch and PVA on the drug release profile. The three-dimensional plots gave us an idea about the contribution of each factor on the release kinetics. Hence this novel polymer of starch and polyvinyl alcohol can be utilized for control release of the drug from a targeted delivery device.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research