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Antibiotic resistance has increased sharply, while the pace for the development of new antimicrobials has slowed down. Plants provide an alternative source for new drugs. This study aimed to screen extracts from  Cissus welwitschii  and  Triumfetta welwitschii  for antibacterial activity against  Escherichia coli  and  Bacillus cereus . The tests conducted included a susceptibility determination test, analysis of the effect of  T. welwitschii  on cell wall integrity, and transport across the membrane. It was found that the  T. welwitschii  methanol extracts were more effective than the water extracts and had the lowest minimum inhibitory concentration and minimum bactericidal concentration at 0.125 mg/mL and 0.5 mg/mL, respectively, against  E. coli  and  B. cereus . The  C. welwitschii  extract caused the most drug accumulation in  E. coli . In  B. cereus , no significant drug accumulation was observed. Nucleic acid leakage in  B. cereus  and  E. coli  and protein leakage in  E. coli  were observed after exposure to the  T. welwitschii  extract. The extracts from  T. welwitschii  had greater antibacterial activity than the extracts from  C. welwitschii .  T. welwitschii  may be a potential source of lead compounds for that could be developed into antibacterial agents.

international journal of bacteriology

Antibacterial Effects of Cissus welwitschii and Triumfetta welwitschii Extracts against Escherichia coli and Bacillus cereus