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. The aim of this retrospective study was to examine effect of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) in second-line and further therapy in daily clinical practice.  Methods . Patients with histologically or cytologically proven NSCLC ( n  = 84) treated with erlotinib in second-line ( n  = 34), third-line ( n  = 36), and more-line therapy ( n  = 14) were examined for progression-free survival (PFS), overall survival (OS),  disease control rate (DCR), duration of therapy, and adverse effects.   Results . Median PFS of all lines was 83 days (CI 70.0–96.0), OS was 7 months (CI 4.7–9.3),  DCR was 66.2% (CI 55–77%), and 1-year survival rate was 33% (CI 22–43%), with no significant difference between therapy lines.  Median duration of treatment was 76 days (IQR 39–139.5). Patients with epidermal growth factor receptor mutation (EGFR-M) reached the highest PFS (204 days), as did patients with good performance status (ECOG 0-1: 94 versus ECOG 2-3: 65 days,  P  = 0.035). Patients with EGFR-M also revealed a DCR of 100%. The most frequent side effects were rash (69%) and diarrhoea (41%), without any significant difference between therapy lines. In 24 patients, the treatment dose was reduced and in 18, the therapy was paused.  Conclusion . Erlotinib works in all therapy lines without any significant differences in efficacy and side effects.

Second- and Further-Line Therapy with Erlotinib in Patients with Advanced Non-Small-Cell Lung Cancer in Daily Clinical Practice