Pregnancy Differentially Regulates the Collagens Types I and III in Left Ventricle from Rat Heart | Zendy

Saraí Limón-Miranda | Zendy; Diana Guadalupe Salazar-Enríquez | Zendy; Jesús Muñı́z | Zendy; Mario V. Ramirez-Archila | Zendy; Enrique SánchezPastor | Zendy; Felipa Andrade | Zendy; José G. SoñanezOrganis | Zendy; Edgar Felipe Morán-Palacio | Zendy; Adolfo VirgenOrtiz | Zendy

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Pregnancy Differentially Regulates the Collagens Types I and III in Left Ventricle from Rat Heart

Author(s) -

Saraí Limón-Miranda,

Diana Guadalupe Salazar-Enríquez,

Jesús Muñı́z,

Mario V. Ramirez-Archila,

Enrique SánchezPastor,

Felipa Andrade,

José G. SoñanezOrganis,

Edgar Felipe Morán-Palacio,

Adolfo VirgenOrtiz

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/984785

Subject(s) - ventricle , pregnancy , downregulation and upregulation , western blot , endocrinology , medicine , gene expression , reversion , ventricular remodeling , biology , andrology , heart failure , gene , phenotype , genetics

The pathologic cardiac remodeling has been widely documented; however, the physiological cardiac remodeling induced by pregnancy and its reversion in postpartum are poorly understood. In the present study we investigated the changes in collagen I (Col I) and collagen III (Col III) mRNA and protein levels in left ventricle from rat heart during pregnancy and postpartum. Col I and Col III mRNA expression in left ventricle samples during pregnancy and postpartum were analyzed by using quantitative PCR. Data obtained from gene expression show that Col I and Col III in left ventricle are upregulated during pregnancy with reversion in postpartum. In contrast to gene expression, the protein expression evaluated by western blot showed that Col I is downregulated and Col III is upregulated in left ventricle during pregnancy. In conclusion, the pregnancy differentially regulates collagens types I and III in heart; this finding could be an important molecular mechanism that regulates the ventricular stiffness in response to blood volume overload present during pregnancy which is reversed in postpartum.

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