Stereoselective Synthesis of (+)-α-Conhydrine from R-(+)-Glyceraldehyde | Zendy

Nageshwar Rao Penumati | Zendy; K. Nagaiah | Zendy

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Stereoselective Synthesis of (+)-α-Conhydrine from R-(+)-Glyceraldehyde

Author(s) -

Nageshwar Rao Penumati,

K. Nagaiah

Publication year - 2014

Publication title -

organic chemistry international

Language(s) - English

Resource type - Journals

eISSN - 2090-2018

pISSN - 2090-200X

DOI - 10.1155/2014/982716

Subject(s) - stereoselectivity , chemistry , imine , bromide , amine gas treating , glyceraldehyde , ring closing metathesis , stereochemistry , salt metathesis reaction , metathesis , combinatorial chemistry , organic chemistry , catalysis , polymerization , polymer , dehydrogenase , enzyme

Stereoselective synthesis of (+)-α-Conhydrine was accomplished from protected (R)-(+)-glyceraldehyde, a familiar carbohydrate predecessor. Our synthetic strategy featured the following two key reactions. One is Zn-mediated stereoselective aza-Barbier reaction of imine 6 with allyl bromide to afford chiral homoallylic amine 7, and the other is ring-closing metathesis

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