Open AccessIncreasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose
Author(s) -
Evan Masutani,
Christopher K. Kinoshita,
Travis T. Tanaka,
Andrew K. D. Ellison,
Brandon A. Yoza
Publication year - 2014
Publication title -
international journal of biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 28
eISSN - 1687-8795
pISSN - 1687-8787
DOI - 10.1155/2014/979636
Subject(s) - gelatin , differential scanning calorimetry , thermal stability , scanning electron microscope , chemistry , ultraviolet , substrate (aquarium) , yield (engineering) , irradiation , matrix (chemical analysis) , chemical engineering , materials science , biophysics , chromatography , composite material , biochemistry , organic chemistry , biology , ecology , physics , optoelectronics , nuclear physics , engineering , thermodynamics
The effects of ultraviolet (254 nm) radiation on a hydrated gelatin-glucose matrix were investigated for the development of a physiologically thermostable substrate for potential use in cell scaffold production. Experiments conducted with a differential scanning calorimeter indicate that ultraviolet irradiation of gelatin-glucose hydrogels dramatically increases thermal stability such that no melting is observed at temperatures of at least 90°C. The addition of glucose significantly increases the yield of cross-linked product, suggesting that glucose has a role in cross-link formation. Comparisons of lyophilized samples using scanning electron microscopy show that irradiated materials have visibly different densities.
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