Exposure of a 23F Serotype Strain ofStreptococcus pneumoniaeto Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11) | Zendy

Riana Cockeran | Zendy; Jenny A. Herbert | Zendy; Timothy J. Mitchell | Zendy; Thérèse DixPeek | Zendy; Caroline Dickens | Zendy; Ronald Anderson | Zendy; Charles Feldman | Zendy

Open Access

Exposure of a 23F Serotype Strain ofStreptococcus pneumoniaeto Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)

Author(s) -

Riana Cockeran,

Jenny A. Herbert,

Timothy J. Mitchell,

Thérèse DixPeek,

Caroline Dickens,

Ronald Anderson,

Charles Feldman

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/976347

Subject(s) - two component regulatory system , downregulation and upregulation , streptococcus pneumoniae , response regulator , microbiology and biotechnology , biofilm , strain (injury) , gene , microarray , cigarette smoke , biology , histidine kinase , serotype , regulator , gene expression , bacteria , genetics , bacterial protein , mutant , toxicology , anatomy , antibiotics

Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μ g/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant ( P < 0.014–0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11 , and its cognate response regulator, rr11 , in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research