In SilicoMolecular Docking andIn VitroAntidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines | Zendy

A. Bharathi | Zendy; Selvaraj Mohana Roopan | Zendy; C. S. Vasavi | Zendy; Punnagai Munusami | Zendy; G. A. Gayathri | Zendy; M. Gayathri | Zendy

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In SilicoMolecular Docking andIn VitroAntidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines

Author(s) -

A. Bharathi,

Selvaraj Mohana Roopan,

C. S. Vasavi,

Punnagai Munusami,

G. A. Gayathri,

M. Gayathri

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/971569

Subject(s) - in silico , in vitro , docking (animal) , chemistry , computational biology , pharmacology , combinatorial chemistry , biochemistry , biology , medicine , gene , nursing

An in vitro antidiabetic activity on α -amylase and α –glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5- a ]acridin-2-amines ( 3a – 3f ) were evaluated. Structures of the synthesized molecules were studied by FT-IR, 1 H NMR, 13 C NMR, EI-MS, and single crystal X-ray structural analysis data. An in silico molecular docking was performed on synthesized molecules ( 3a – 3f ). Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α -amylase and α -glucosidase.

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